منابع مشابه
A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.
HOIL-1L and its binding partner HOIP are essential components of the E3-ligase complex that generates linear ubiquitin (Ub) chains, which are critical regulators of NF-κB activation. Using crystallographic and mutational approaches, we characterize the unexpected structural basis for the specific interaction between the Ub-like domain (UBL) of HOIL-1L and the Ub-associated domain (UBA) of HOIP....
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T he posttranslational modification of proteins with ubiquitin and ubiquitin-like proteins (collectively referred to as UBLs) has emerged as a major regulatory mechanism in eukaryotes. UBLs are characterized by a core β-grasp fold and an essential carboxy terminal glycine within a di-glycine motif (1). These features are also found in several prokaryotic sulfur carriers, suggestive of an evolut...
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Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning during neurodevelopment and is important for synaptic plasticity in the mature brain. Moreover, Reelin is expressed in many extraneuronal tissues; yet the roles of peripheral Reelin are largely unknown. In the brain, many of Reelin's functions are mediated by a molecular signaling cascade that involves tw...
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In this work we analyze objects with non-canonical case markers in Turkish. We show that semantic factors give rise to non-canonical case marking and try to determine criteria to decide on the grammatical function status of non-canonical objects. We conclude that ablative partitives and dative objects participating in an affectedness alternation should be analyzed as straightforward objects (OB...
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In this paper the ultraalter properties of canonical frames are used to produce a non-standard map between canonical frames of diierent cardinalities. While this map is not a p-morphism, it is presented as a step towards the full understanding of canonical structures.
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2021
ISSN: 2218-273X
DOI: 10.3390/biom11020139